I-05 POST-TRAUMATIC OSTEOARTHRITIS REVISITED

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Post-Traumatic Osteoarthritis: Biologic Approaches to Treatment

Joint injuries are becoming increasingly common, with young adults between the ages of 1844 seeking medical attention for joint sprains, dislocation, fractures, anterior cruciate ligament (ACL) and meniscal tears, and others. The cascade of events that follow these joint injuries have been shown to increase the risk of post-traumatic osteoarthritis (PTOA) by 2050% (Anderson et al,2011). Therefo...

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The genetic contribution to severe post-traumatic osteoarthritis

OBJECTIVE to compare the combined role of genetic variants loci associated with risk of knee or hip osteoarthritis (OA) in post-traumatic (PT) and non-traumatic (NT) cases of clinically severe OA leading to total joint replacement. METHODS A total of 1590 controls, 2168 total knee replacement (TKR) cases (33.2% PT) and 1567 total hip replacement (THR) cases (8.7% PT) from 2 UK cohorts were ge...

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A Clinically Relevant Relevant Post-Traumatic Osteoarthritis Mouse Model

.............................................................................................................................. ii Co-Authorship Statement................................................................................................... iii Acknowledgments.............................................................................................................. iv List of Tab...

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Early Intervention with cdk9 Inhibitors to Prevent Post-Traumatic Osteoarthritis

Post-traumatic osteoarthritis (PTOA) is a common long-term consequence of joint injuries such as anterior cruciate ligament (ACL) rupture. In this study we used a tibial compression overload mouse model to compare knee injury induced at low speed (1mm/s), which creates an avulsion fracture, to injury induced at high speed (500mm/s), which induces midsubstance tear of the ACL. Mice were sacrific...

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Computational analysis applied to the study of post-traumatic osteoarthritis

Approved: ____________________________________ Thesis Supervisor ____________________________________ Title and Department ____________________________________ Date COMPUTATIONAL ANALYSIS APPLIED TO THE STUDY OF POSTTRAUMATIC OSTEOARTHRITIS by Curtis Michael Goreham-Voss A thesis submitted in partial fulfillment of the requirements for the Doctor of Philosophy degree in Biomedical Engineering i...

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ژورنال

عنوان ژورنال: Osteoarthritis and Cartilage

سال: 2010

ISSN: 1063-4584

DOI: 10.1016/s1063-4584(10)60010-6